Sr Alessandra Smerilli, F.M.A. was born in Vasto (Ch) on 14 November 1974, and became a Daughter of Mary Help of Christians in 1997 after a period of theological formation at the Pontifical Lateran University.
She graduated in Economics from Roma Tre University in 2001, and obtained a PhD in Political Economy from La Sapienza University of Rome (2006) and a PhD in Economics from East Anglia University (Norwich, UK 2014). In 2016, she carried out research activities at the University of Pennsylvania.
Her research interests are related to economic theories of cooperation and value-based organisations. She has authored several publications on these topics.
She is full professor of Political Economy at the Auxilium Faculty of Education. She has taught Economics of Cooperation at the Catholic University of the Sacred Heart (Milan) and the LUMSA University (Rome), Economics, Ethics and Finance at the Pontifical Salesian University (Rome) and International Economics at the Pontifical Lateran University.
From 2006 to 2021, she worked with the Italian Episcopal Conference for the Social Weeks of Catholics.
In 2018 she participated as an auditor at the Synod on "Youth, faith, vocational discernment". From 2019 to 2024, she was a Counsellor of Vatican City State.
Since April 2020 she worked with the Dicastery for Promoting Integral Human Development as Coordinator of the Task Force Economy in the Vatican Covid-19 Commission and since March 2021 she has held the position of Undersecretary at the same Dicastery.
On 26 August 2021, the Holy Father appointed her as interim Secretary of the Dicastery and Delegate for the Vatican Covid-19 Commission, confirming her in this role on 23 December 2021.
On 23 April 2022, Pope Francis appointed her Secretary of the Dicastery for Promoting Integral Human Development.
In September 2023, she was appointed to the Board of Directors of the Laudato Si' Higher Education Center.
On 30 June 2026, Pope Leo XIV appointed her Prefect of the Dicastery for Promoting Integral Human Development.